help
help > RE: Correction for global signal
Jul 18, 2013 12:07 AM | Alfonso Nieto-Castanon - Boston University
RE: Correction for global signal
Dear Natalia,
By default the conn toolbox uses CompCor, instead of global signal regression, to address potential subject-movement and physiological confounding effects without the risk of artificially introducing anticorrelations into your functional connectivity estimates, so generally I would not recommend using global signal regression instead. See this thread (https://www.nitrc.org/forum/forum.php?th...), or this reference (Chai X.J., Nieto-Castanon A., Ongur D., Whitfield-Gabrieli S. (2012) Anticorrelations in resting state networks without global signal regression. NeuroImage 59(2):1420-1428) for more details about this issue.
That said, if you still want to regress out the global signal you may do so (approximately) by entering the 'grey-matter' ROI into the 'confounds' list in the 'Preprocessing' tab (and probably removing the White-matter and CSF ROIs if you do not want to use the CompCor strategy), or (perhaps more precisely) by adding a new ROI in the 'Setup->ROIs' tab that encompass the entire brain (e.g. brainmask.nii if you are working on normalized volumes) and entering this ROI instead into the 'confounds' list in the 'Preprocessing' tab.
Hope this helps
Alfonso
Originally posted by Natalia Yakunina:
By default the conn toolbox uses CompCor, instead of global signal regression, to address potential subject-movement and physiological confounding effects without the risk of artificially introducing anticorrelations into your functional connectivity estimates, so generally I would not recommend using global signal regression instead. See this thread (https://www.nitrc.org/forum/forum.php?th...), or this reference (Chai X.J., Nieto-Castanon A., Ongur D., Whitfield-Gabrieli S. (2012) Anticorrelations in resting state networks without global signal regression. NeuroImage 59(2):1420-1428) for more details about this issue.
That said, if you still want to regress out the global signal you may do so (approximately) by entering the 'grey-matter' ROI into the 'confounds' list in the 'Preprocessing' tab (and probably removing the White-matter and CSF ROIs if you do not want to use the CompCor strategy), or (perhaps more precisely) by adding a new ROI in the 'Setup->ROIs' tab that encompass the entire brain (e.g. brainmask.nii if you are working on normalized volumes) and entering this ROI instead into the 'confounds' list in the 'Preprocessing' tab.
Hope this helps
Alfonso
Originally posted by Natalia Yakunina:
Dear all,
Is there a way to regress against the global signal in CONN?
Thank you!
Best,
Natalia
Is there a way to regress against the global signal in CONN?
Thank you!
Best,
Natalia
Threaded View
| Title | Author | Date |
|---|---|---|
| Natalia Yakunina | Jul 15, 2013 | |
| Alfonso Nieto-Castanon | Jul 18, 2013 | |
| Sascha Froelich | Sep 9, 2016 | |
| Nobody | Nov 20, 2020 | |
| Alfonso Nieto-Castanon | Sep 9, 2016 | |
| Ben R | Apr 8, 2020 | |
| Scott Burwell | Sep 9, 2016 | |
| Natalia Yakunina | Jul 23, 2013 | |
| Jeff Browndyke | Aug 29, 2015 | |
| Alfonso Nieto-Castanon | Aug 31, 2015 | |
| Jeff Browndyke | Aug 31, 2015 | |
| Jeff Browndyke | Aug 28, 2015 | |
| Alfonso Nieto-Castanon | Aug 28, 2015 | |
| Jeff Browndyke | Aug 29, 2015 | |