DRAMMS is for 2D, 3D, 3.5D, 4D and population-wise deformable image registration. Typical applications include,

-- Cross-subject registration;

-- Single- or Multi-site data;

-- Single- or Multi-modal registration;

-- Longitudinal registration for quantifying changes;

-- Registration under missing correspondences.

-- Group-wise registration for unbiased atlas construction.

DRAMMS runs in command line in UNIX/Mac OS, It accepts Nifti/ANALYZE/MetaImage image formats. It is fully-automatic --- takes two input images, and generates a registered image and (optionally) the deformation field; no user initialization or interaction is needed.

More information (installation, tutorial, manual, demonstration, FAQ, etc) can be found at http://www.rad.upenn.edu/sbia/software/d... .

4d-dramms: https://www.nitrc.org/projects/dramms4d/
group-wise dramms: https://www.nitrc.org/projects/popdramms...